Geroscience Publications

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Publications
Articles
Belsky, D. W.; Caspi, A.; Houts, R.; Cohen, H. J.; Corcoran, D. L.; Danese, A.; Harrington, H.; Israel, S.; Levine, M. E.; Schaefer, J. D.; Sugden, K.; Williams, B.; Yashin, A. I.; Poulton, R. & Moffitt, T. E. (2015), ‘Quantification of biological aging in young adults.’, Proc Natl Acad Sci U S A 112(30), E4104–E4110.

Benz, C. C. & Yau, C. (2008), ‘Ageing, oxidative stress and cancer: paradigms in parallax.’, Nat Rev Cancer 8(11), 875–879.

Burch, J. B.; Augustine, A. D.; Frieden, L. A.; Hadley, E.; Howcroft, T. K.; Johnson, R.; Khalsa, P. S.; Kohanski, R. A.; Li, X. L.; Macchiarini, F.; Niederehe, G.; Oh, Y. S.; Pawlyk, A. C.; Rodriguez, H.; Rowland, J. H.; Shen, G. L.; Sierra, F. & Wise, B. C. (2014), ‘Advances in geroscience: impact on healthspan and chronic disease.’, J Gerontol A Biol Sci Med Sci 69 Suppl 1, S1–S3.

Burd, C. E.; Gill, M. S.; Niedernhofer, L. J.; Robbins, P. D.; Austad, S. N.; Barzilai, N. & Kirkland, J. L. (2016), ‘Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.’, J Gerontol A Biol Sci Med Sci 71(11), 1388–1394.

Ferrucci, L. (2016), ‘Commentary: Life course epidemiology embraces geroscience.’, Int J Epidemiol 45(4), 1015–1019.

Ferrucci, L.; Cooper, R.; Shardell, M.; Simonsick, E. M.; Schrack, J. A. & Kuh, D. (2016), ‘Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience.’, J Gerontol A Biol Sci Med Sci 71(9), 1184–1194.

Figueira, I.; Fernandes, A.; Mladenovic Djordjevic, A.; Lopez-Contreras, A.; Henriques, C. M.; Selman, C.; Ferreiro, E.; Gonos, E. S.; Trejo, J. L.; Misra, J.; Rasmussen, L. J.; Xapelli, S.; Ellam, T. & Bellantuono, I. (2016), ‘Interventions for age-related diseases: Shifting the paradigm.’, Mech Ageing Dev 160, 69–92.

Franceschi, C. (2017), ‘Healthy ageing in 2016: Obesity in geroscience – is cellular senescence the culprit?’, Nat Rev Endocrinol 13(2), 76–78.

Franceschi, C. & Garagnani, P. (2016), ‘Suggestions from Geroscience for the Genetics of Age-Related Diseases.’, PLoS Genet 12(11), e1006399.

Harkema, L.; Youssef, S. A. & de Bruin, A. (2016), ‘Pathology of Mouse Models of Accelerated Aging.’, Vet Pathol 53(2), 366–389.

Hodes, R. J.; Sierra, F.; Austad, S. N.; Epel, E.; Neigh, G. N.; Erlandson, K. M.; Schafer, M. J.; LeBrasseur, N. K.; Wiley, C.; Campisi, J.; Sehl, M. E.; Scalia, R.; Eguchi, S.; Kasinath, B. S.; Halter, J. B.; Cohen, H. J.; Demark-Wahnefried, W.; Ahles, T. A.; Barzilai, N.; Hurria, A. & Hunt, P. W. (2016), ‘Disease drivers of aging.’, Ann N Y Acad Sci 1386(1), 45–68.

Howcroft, T. K.; Campisi, J.; Louis, G. B.; Smith, M. T.; Wise, B.; Wyss-Coray, T.; Augustine, A. D.; McElhaney, J. E.; Kohanski, R. & Sierra, F. (2013), ‘The role of inflammation in age-related disease.’, Aging (Albany NY) 5(1), 84–93.

Huffman, D. M.; Justice, J. N.; Stout, M. B.; Kirkland, J. L.; Barzilai, N. & Austad, S. N. (2016), ‘Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience.’, J Gerontol A Biol Sci Med Sci 71(11), 1395–1406.

Ingram, D. K. & Roth, G. S. (2015), ‘Calorie restriction mimetics: can you have your cake and eat it, too?’, Ageing Res Rev 20, 46–62.

Johnson, S. C. & Kaeberlein, M. (2016), ‘Rapamycin in aging and disease: maximizing efficacy while minimizing side effects.’, Oncotarget 7(29), 44876–44878.

Justice, J.; Miller, J. D.; Newman, J. C.; Hashmi, S. K.; Halter, J.; Austad, S. N.; Barzilai, N. & Kirkland, J. L. (2016), ‘Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.’, J Gerontol A Biol Sci Med Sci 71(11), 1415–1423.

Kaeberlein, M.; Creevy, K. E. & Promislow, D. E. L. (2016), ‘The dog aging project: translational geroscience in companion animals.’, Mamm Genome 27(7-8), 279–288.

Kaeberlein, M.; Rabinovitch, P. S. & Martin, G. M. (2015), ‘Healthy aging: The ultimate preventative medicine.’, Science 350(6265), 1191–1193.

Kennedy, B. K.; Berger, S. L.; Brunet, A.; Campisi, J.; Cuervo, A. M.; Epel, E. S.; Franceschi, C.; Lithgow, G. J.; Morimoto, R. I.; Pessin, J. E.; Rando, T. A.; Richardson, A.; Schadt, E. E.; Wyss-Coray, T. & Sierra, F. (2014), ‘Geroscience: linking aging to chronic disease.’, Cell 159(4), 709–713.

Kirkland, J. L.; Stout, M. B. & Sierra, F. (2016), ‘Resilience in Aging Mice.’, J Gerontol A Biol Sci Med Sci 71(11), 1407–1414.

Kohanski, R. A.; Deeks, S. G.; Gravekamp, C.; Halter, J. B.; High, K.; Hurria, A.; Fuldner, R.; Green, P.; Huebner, R.; Macchiarini, F. & Sierra, F. (2016), ‘Reverse geroscience: how does exposure to early diseases accelerate the age-related decline in health?’, Ann N Y Acad Sci 1386(1), 30–44.

Martin, G. M. (2017), ‘Views on the ethical struggle for universal, high quality, affordable health care and its relevance for gerontology.’, Exp Gerontol 87(Pt B), 182–189.

Martin, G. M. (2016), ‘Geroscience: Addressing the mismatch between its exciting research opportunities, its economic imperative and its current funding crisis.’, Exp Gerontol.

Mattison, J. A.; Colman, R. J.; Beasley, T. M.; Allison, D. B.; Kemnitz, J. W.; Roth, G. S.; Ingram, D. K.; Weindruch, R.; de Cabo, R. & Anderson, R. M. (2017), ‘Caloric restriction improves health and survival of rhesus monkeys.’, Nat Commun 8, 14063.

Melov, S. (2016), ‘Geroscience approaches to increase healthspan and slow aging.’, F1000Res 5.

Meneses, K.; Benz, R.; Azuero, A.; Jablonski-Jaudon, R. & McNees, P. (2015), ‘Multimorbidity and breast cancer.’, Semin Oncol Nurs 31(2), 163–169.

Moffitt, T. E.; Belsky, D. W.; Danese, A.; Poulton, R. & Caspi, A. (2017), ‘The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda.’, J Gerontol A Biol Sci Med Sci 72(2), 210–215.

Newgard, C. B. & Pessin, J. E. (2014), ‘Recent progress in metabolic signaling pathways regulating aging and life span.’, J Gerontol A Biol Sci Med Sci 69 Suppl 1, S21–S27.

Newman, J. C.; Milman, S.; Hashmi, S. K.; Austad, S. N.; Kirkland, J. L.; Halter, J. B. & Barzilai, N. (2016), ‘Strategies and Challenges in Clinical Trials Targeting Human Aging.’, J Gerontol A Biol Sci Med Sci 71(11), 1424–1434.

Roth, G. S. (2005), ‘Caloric restriction and caloric restriction mimetics: current status and promise for the future.’, J Am Geriatr Soc 53(9 Suppl), S280–S283.

Roth, G. S. & Ingram, D. K. (2016), ‘Manipulation of health span and function by dietary caloric restriction mimetics.’, Ann N Y Acad Sci 1363, 5–10.

Roth, G. S.; Ingram, D. K. & Joseph, J. A. (2007), ‘Nutritional interventions in aging and age-associated diseases.’, Ann N Y Acad Sci 1114, 369–371.

Roth, G. S.; Lane, M. A. & Ingram, D. K. (2005), ‘Caloric restriction mimetics: the next phase.’, Ann N Y Acad Sci 1057, 365–371.

Seals, D. R.; Justice, J. N. & LaRocca, T. J. (2016), ‘Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.’, J Physiol 594(8), 2001–2024.

Seals, D. R. & Melov, S. (2014), ‘Translational geroscience: emphasizing function to achieve optimal longevity.’, Aging (Albany NY) 6(9), 718–730.

Sierra, F. (2016), ‘Moving Geroscience Into Uncharted Waters.’, J Gerontol A Biol Sci Med Sci 71(11), 1385–1387.

Sierra, F. (2016), ‘The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span.’, Cold Spring Harb Perspect Med 6(4), a025163.

Sonntag, W. E. & Ungvari, Z. (2016), ‘GeroScience: understanding the interaction of processes of aging and chronic diseases.’, Age (Dordr) 38(5-6), 377–378.

Treuting, P. M.; Snyder, J. M.; Ikeno, Y.; Schofield, P. N.; Ward, J. M. & Sundberg, J. P. (2016), ‘The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.’, Vet Pathol 53(2), 244–249.

Vaiserman, A. M.; Lushchak, O. V. & Koliada, A. K. (2016), ‘Anti-aging pharmacology: Promises and pitfalls.’, Ageing Res Rev 31, 9–35.

Vaiserman, A. M. & Marotta, F. (2016), ‘Longevity-Promoting Pharmaceuticals: Is it a Time for Implementation?’, Trends Pharmacol Sci 37(5), 331–333.

Books and Book Chapters
Sierra, F. & Kohanski, eds., (2015), Advances in Geroscience, Springer Publishers.

Sierra, F.; Fillit, Rockwood, W., eds., (2015, in press), Brocklehurst Textbook of Geriatric Medicine and Gerontology, 8th edition, Elsevier, Philadelphia, chapter Chapter 7 Geroscience.

Sierra, F.; Olshansky SJ, Marting G.M. & Kirkland, JS, eds., (2015), Aging – The Longevity Dividend, Cold Spring Harbor Perspectives in Medicine series, Cold Springs Harbor Laboratory Press, Cold Spring Harbor, New York, chapter Introduction: The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span, pp. 1-14.